Britton Chance (1913-2010) was a biochemist and biophysicist as well as a pioneer in the field of biomedical optics. Chance received his Ph.D. in Physical Chemistry from the University of Pennsylvania in 1940 and his Ph.D. in Biology and Physiology from Cambridge University in 1942. Over the course of his nearly eight decade career, Chance was dedicated to the application and transfer of basic scientific research and technology to clinical medicine. The Britton Chance Papers contain correspondence, research notes, experimental data, publication materials, and photographs stemming from Chance's life as a biochemist, biophysicist, and yachtsman. The collection is broken up into fifteen series that document every aspect of his scientific work.

Edward Uhler Condon was a theoretical physicist at Princeton University and Westinghouse Laboratories who later served as director of the National Bureau of Standards (1945-1951), and as the director of research and development (1951-1954) and consulting physicist (1954-1974) at Corning Glass Works. The Condon Papers includes correspondence, notebooks, writings, photographs, and other materials concerning Condon's education, teaching, and his government, industrial, and academic.

A bacteriologist from MIT, Salvador E. Luria's work with Max Delbruck on bacteriophage demonstrated that bacterial resistance to certain phages arose through genetic mutations. His later work showed that phages also mutate genetically. He received the Nobel Prize in Physiology or Medicine in 1969 with Max Delbruck and Alfred D. Hershey. The collection is organized into seven series: I. Correspondence, 1938-1992 ; IIa. Subject Files, 1938-1990 ; IIb. Personal Material. 1923-1991 ; III. Works by Luria, 1938-1987 ; IV. Works by Others, 1944-1990 ; V. Research Notes and Notebooks, 1941-1979 ; VI. Course Material, 1931-1991 ; VII. Photographs and Negatives, 1957-1982. Arrangement: Alphabetical by folder title and then chronological within each folder.

A physicist with the Theoretical Division of Los Alamos Scientific Laboratory, Walter Goad became interested in molecular biology in the mid-1960s, devoting nearly all of his research to the analysis, storage and retrieval of information relating to nucleic acid sequences by the early 1970s. He was among the founders of GenBank, the world's first nucleic acid database, and was influential in the development of computational techniques for the analysis of DNA sequences. In the late 1980s, he served on the steering committee overseeing the establishment of the Human Genome Project. The Goad Papers relate primarily to the establishment and early operation of GenBank, the early phases of the Human Genome Project, and, more generally, to Goad's role as godfather of the new field of bioinformatics.